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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8289909ecb98567b2000a1c52a14bdee2e12530425bb61217c50b55da7dae90' 
  AND token = 'ObBPkZOjp2x2h9n6hXnn8RE0rL/dMp9kN/d4uHHsFic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00053

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}