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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2196c1099a225a9bfbaafac8ccbb2c87817f40d6f3b9d9f89457857d5020756' 
  AND token = 'CfvaXVHn5UyK4aJk8IW8r+QGAy3SsLTjPOq+s6DRRDU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}